What a cute baby quilt! I am sure the baby likes the feel of the different fabrics and the colors are wonderful!

I have made a few baby quilts using both flannel and cotton with no problems. I do not prewash my fabrics but the care labels said that the fabrics had been preshrunk and that shrinkage would be less than 1%. I mixed and matched the front but used cotton for the back and binding. I would say the extra step of prewashing would make it even less scary...can't wait to see what you make!