You definitely can!!! I would bet money that most of us started out on a traditional "home" machine! I started off with a Janome Sewist 525S (which I still have!) and made my very first quilt on it!

http://forum.missouriquiltco.com/mem...ne-7-2014.html

Like others have said... start off small (think baby or throw sized) and work your way up once you are comfortable.

Can't wait to see what you create!