You asked if it is OK to sandwich a quilt in sections due to space issues-----I would have to say that sandwiching, and basting or pin- basting is extremely important to the success of your finished product. I believe that the entire quilt should be sandwiched and secured before you begin quilting. Could you lay it out on a floor? I lay on a carpeted area and make sure it is flat in all areas before securing and quilting. Hope this helps.