Are you quilting lines or free motion?
Especially for lines I think you need the whole thing basted because you want to work from the middle outward and you can't do that if half of the quilt isn't ready to be quilted.
Are you pinning or spray basting? Personally I prefer spray but different people like different methods. When you spray baste you can do that one section at a time but you generally baste the entire thing before the quilting begins.
As far as starting and stopping, I usually try to start in an area that will be covered by the binding. For middle sections my current machine has a "fix stitch" which makes multiple stitches in the same spot, on my old machine that did not have this I back stitched.
Good luck. Quilting is exciting but scary to get started.



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