The only thing I can impart on this topic is to start in the middle and work your way out. Sometimes, if the quilt is too large and the 'throat' on the machine too shallow, it is recommended to do the quilting in strips. For instance, one of my huge UFOs is a king-size that I've parceled into three separate pieces to quilt. Hope someone with more experience with chime in and direct you to some tried and true assistance.